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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 1
1983 6
1984 14
1985 33
1986 48
1987 75
1988 81
1989 91
1990 108
1991 128
1992 123
1993 132
1994 158
1995 184
1996 159
1997 157
1998 150
1999 138
2000 130
2001 134
2002 125
2003 142
2004 143
2005 121
2006 125
2007 126
2008 121
2009 122
2010 121
2011 126
2012 148
2013 171
2014 168
2015 147
2016 184
2017 186
2018 191
2019 187
2020 177
2021 99
2022 27
2023 24
2024 2

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4,725 results

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Page 1
Proto-oncogenes in development and cancer.
Torry DS, Cooper GM. Torry DS, et al. Am J Reprod Immunol. 1991 Apr;25(3):129-32. doi: 10.1111/j.1600-0897.1991.tb01080.x. Am J Reprod Immunol. 1991. PMID: 1930640 Review.
Genetic studies of RNA tumor viruses have provided insights into the relationships and differences of the genes responsible for normal development and cancer. The presence of discrete genes (oncogenes) within the genome of oncogenic retroviruses is responsible for t …
Genetic studies of RNA tumor viruses have provided insights into the relationships and differences of the genes responsible for norma …
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC. Barbie DA, et al. Nature. 2009 Nov 5;462(7269):108-12. doi: 10.1038/nature08460. Epub 2009 Oct 21. Nature. 2009. PMID: 19847166 Free PMC article.
Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some cases, KRAS has remained refractory to this approach. A complementary strategy for targeting KRAS is to identify gene products that, …
Although the identification of specific oncogenes has led to the development of clinically effective, molecularly targeted therapies in some …
PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression.
Liu M, Yao B, Gui T, Guo C, Wu X, Li J, Ma L, Deng Y, Xu P, Wang Y, Yang D, Li Q, Zeng X, Li X, Hu R, Ge J, Yu Z, Chen Y, Chen B, Ju J, Zhao Q. Liu M, et al. Theranostics. 2020 Mar 15;10(10):4437-4452. doi: 10.7150/thno.42047. eCollection 2020. Theranostics. 2020. PMID: 32292506 Free PMC article.
The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the mechanisms underlying c-Myc-mediated gene repression in the context of cancer remain less clear. ...H4R3me2s also colocalized with th …
The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the …
The transcriptional landscape and mutational profile of lung adenocarcinoma.
Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, Bleazard T, Lee J, Jung YJ, Kim JO, Shin JY, Yu SB, Kim J, Lee ER, Kang CH, Park IK, Rhee H, Lee SH, Kim JI, Kang JH, Kim YT. Seo JS, et al. Genome Res. 2012 Nov;22(11):2109-19. doi: 10.1101/gr.145144.112. Epub 2012 Sep 13. Genome Res. 2012. PMID: 22975805 Free PMC article.
Candidates for novel driver mutations were also identified in genes newly implicated in lung adenocarcinoma such as LMTK2, ARID1A, NOTCH2, and SMARCA4. We found 45 fusion genes, eight of which were chimeric tyrosine kinases involving ALK, RET, ROS1, FGFR2, AXL, and …
Candidates for novel driver mutations were also identified in genes newly implicated in lung adenocarcinoma such as LMTK2, ARID1A, NO …
Bcl-2-related antisense therapy.
Gutiérrez-Puente Y, Zapata-Benavides P, Tari AM, López-Berestein G. Gutiérrez-Puente Y, et al. Semin Oncol. 2002 Jun;29(3 Suppl 11):71-6. doi: 10.1053/sonc.2002.34058. Semin Oncol. 2002. PMID: 12138400 Review.
Antisense oligonucleotides directed toward the open reading frame of the bcl-2 gene have been used to inhibit Bcl-2 expression. Inhibition of Bcl-2 expression sensitizes lymphoma and leukemia cells to radiation and chemotherapy. ...
Antisense oligonucleotides directed toward the open reading frame of the bcl-2 gene have been used to inhibit Bcl-2 expression. Inhib …
The MYC oncogene is a global regulator of the immune response.
Casey SC, Baylot V, Felsher DW. Casey SC, et al. Blood. 2018 May 3;131(18):2007-2015. doi: 10.1182/blood-2017-11-742577. Epub 2018 Mar 7. Blood. 2018. PMID: 29514782 Free PMC article. Review.
The MYC proto-oncogene is a gene product that coordinates the transcriptional regulation of a multitude of genes that are essential to cellular programs required for normal as well as neoplastic cellular growth and proliferation, including cell cycle, self-renewal, …
The MYC proto-oncogene is a gene product that coordinates the transcriptional regulation of a multitude of genes that are esse …
Bladder Cancer and Genetic Mutations.
Zhang X, Zhang Y. Zhang X, et al. Cell Biochem Biophys. 2015 Sep;73(1):65-9. doi: 10.1007/s12013-015-0574-z. Cell Biochem Biophys. 2015. PMID: 27352265 Review.
The invasive bladder cancers were determined for the presence of gene mutations on p53 suppressor gene. The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene. The bladder cancer studies have suggested that 70 % of bla …
The invasive bladder cancers were determined for the presence of gene mutations on p53 suppressor gene. The 18 different bladd …
Oncogenes and cancer.
Lynch DH. Lynch DH. Am J Reprod Immunol Microbiol. 1987 Sep;15(1):24-8. doi: 10.1111/j.1600-0897.1987.tb00145.x. Am J Reprod Immunol Microbiol. 1987. PMID: 3322067 Review.
Early studies designed to investigate the molecular basis of oncogenesis indicated the existence of discrete genes which could cause neoplastic transformation of normal cells in vitro. ...These genes (termed proto-oncogenes) have been found to code for proteins whic …
Early studies designed to investigate the molecular basis of oncogenesis indicated the existence of discrete genes which could cause …
Cyclin D and oncogenesis.
Motokura T, Arnold A. Motokura T, et al. Curr Opin Genet Dev. 1993 Feb;3(1):5-10. doi: 10.1016/s0959-437x(05)80334-x. Curr Opin Genet Dev. 1993. PMID: 8453274 Review.
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumo …
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 …
Oncogenes, Proto-Oncogenes, and Lineage Restriction of Cancer Stem Cells.
Brown G. Brown G. Int J Mol Sci. 2021 Sep 7;22(18):9667. doi: 10.3390/ijms22189667. Int J Mol Sci. 2021. PMID: 34575830 Free PMC article. Review.
In principle, an oncogene is a cellular gene (proto-oncogene) that is dysfunctional, due to mutation and fusion with another gene or overexpression. ...
In principle, an oncogene is a cellular gene (proto-oncogene) that is dysfunctional, due to mutation and fusion with another gene …
4,725 results